Summary from the GEO: "The paradox of tumor immunology is that tumor infiltrating lymphocytes (TILs) are dysfunctional in situ and yet are capable of stem cell-like behavior with self-renewal, massive expansion, multipotency, and eradication of large metastatic tumors. Here we report that the overabundance of potassium in the tumor microenvironment (TME) can explain both phenomena." Overall design...

Summary from GEO: "Cancer cells interact with a wide variety of other cell types, but our understanding of microenvironmental heterogeneity and how it influences tumor phenotypes is limited. While single-cell RNA-seq (scRNA-seq) has helped define these TME cell types, it provides limited information on the mechanisms that define how individual tumor cells interact with TME. Here, we integrate spatial...

Summary from GEO: "Melanoma brain metastases (MBM) and leptomeningeal metastases (LMM) are two manifestations of melanoma CNS metastasis with vastly different survival outcomes. Using single cell RNA-Seq analysis we uncovered a unique, immune-suppressed T-cell landscape in the LMM microenvironment distinct from that of brain and skin metastases. An LMM patient with an unusually long survival demonstrated...

Summary form GEO: "Macrophages accumulate with glioblastoma multiforme (GBM) progression, and can be acutely targeted via inhibition of colony stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models. However, whether and how resistance emerges in response to sustained CSF-1R blockade is unknown. Here, we investigate whether long-term CSF-1R inhibition can stably regress...

Summary from GEO: "Glioblastoma multiforme (GBM) is the most aggressive form of glioma, and is notorious for its terminal prognosis and lack of responsiveness to current treatment approaches. The brain tumor microenvironment (TME) represents a largely untapped reservoir of therapeutic target options in GBM. Here we have focused on the interplay between glioma cells and tumor-associated macrophages/...

Raw data (multiplexed IF and NanoString) supporting the findings of the publication "Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma." The processed multiplexed IF data and sample ID key are available at (https://zenodo.org/record/7627120). All code used to produce the results of this study are available at https://github.com/cBio-MSKCC/Halo_Melanoma_IL2. Note:...

Description from Zenodo: "The processed multiplexed IF data and sample ID corresponding to the raw data in record (https://zenodo.org/record/4300912#.Y-WGBuzMKY-). All code used to produce the results of this study are available at https://github.com/cBio-MSKCC/Halo_Melanoma_IL2." Note: The GitHub link provided by the dataset creators no longer works.

Description from Zenodo: "Processed metabolomics and sample data associated with "Immunometabolic coevolution defines unique microenvironmental niches in ccRCC"."